The AREST CF program has grown from an early surveillance Lyla Smilingprogram initiated in Perth in 1999 that involved obtaining bronchoalveolar lavage (BAL) to evaluate pulmonary (lung) infection and inflammation and infant lung function testing.


The program was extended to include measurement of preschool lung function in 2003 and chest computed tomography (CT) scanning in 2005.


The Royal Childrens Hospital based in Melbourne  joined the program in 2005 and we have been successfully operating as a single entity since.


The current program consists of a core platform, containing both routine clinical and research aspects, and additional research studies. Children are assessed at various times, including: annual surveillance assessment; at routine clinic attendances; on hospitalisation for respiratory exacerbations; and following treatment to eradicate pulmonary infection with Pseudomonas aeruginosa.